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KMID : 1103720070560050479
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Journal of the Korean Society of Radiology
2007 Volume.56 No. 5 p.479 ~ p.481
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Propylthiouracil-induced Diffuse Pulmonary Hemorrhage: A Case Report with the Clinical and Radiologic Findings
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Cho Young-Jun
Choi Soo-Jeun
Kim Jung-Suk
Kim Ji-Young
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Abstract
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Propylthiouracil (PTU) is a drug that’s used to manage hyperthyroidism and it can, on rare occasions, induce antineutrophil cytoplasmic antibody-associated vasculitis that involves multiple organ systems and it can also cause extremely rare isolated or diffuse pulmonary hemorrhage. We report here on a case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for five years. The patient is a 33-year-old woman who presented with hemoptysis. Simple chest radiographs and the chest CT showed bilateral ground-glass opacity, consolidation and pulmonary arterial hypertension. The bronchoalveolar lavage fluid revealed alveolar hemorrhage. The laboratory values showed increased perinuclear-antineutrophil cytoplasmic antibody (p-ANCA) and anti-peroxidase antibody titers.
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KEYWORD
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Pulmonary hemorrhage, CT, Hyperthyroidism, Vasculitis, Drug, Side effects
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